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Line Pedersen, Manja Idorn, Gitte H. Olofsson, Britt Lauenborg, Intawat Nookaew, Rasmus Hvass Hansen, Helle Hjorth Johannesen, Jürgen C. Becker, Katrine S. Pedersen, Christine Dethlefsen, Jens Nielsen, Julie Gehl, Bente K. Pedersen, Per thor Straten, & Pernille Hojman

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

Cell Metabolism. 2016; 23(3): 554-562. doi: 10.1016/j.cmet.2016.01.011.

 

Abstract

Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced upregulation of pathways associated with immune function. NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise. Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of β-adrenergic signaling blunted training-dependent tumor inhibition. Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.

目的・結果・結論を示すために使われているフレーズに注目してください。

 

＜最初の一文で背景＞

Regular exercise reduces the risk of cancer and disease recurrence.

  

＜問題点＞

Yet the mechanisms behind this protection remain to be elucidated.

 

＜本文で示す結果＞

In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models.

Microarray analysis revealed training-induced upregulation of pathways associated with immune function.

NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise.

Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of β-adrenergic signaling blunted training-dependent tumor inhibition.

Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation.

 

＜結論＞

Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.

　

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このAbstractは、まず最初の一文で研究の背景を説明後、

Yet ～ remain to be elucidated.　/　しかし、～の解明が残されている

といって問題点、裏をとれば研究の目的（運動によって癌や病気の再発を予防するメカニズムを解明することが、この研究の目的であると読み取れます）を、

In this study, ～　/　本研究では、～

といって本文（Results）で示す結果の要約を5つ述べています。Resultsを読む際は、この結果がどのような実験を行なって得られた結果なのか、にも注目してください。

最後の一文を

Together, these results ～　/　以上より、これらの結果は～

で始めて結論を、述べています。