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Takao Hashiguchi, Toyoyuki Ose, Marie Kubota, Nobuo Maita, Jun Kamishikiryo, Katsumi Maenaka, & Yusuke Yanagi

Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM

Nature Structural & Molecular Biology. 2011; 18(2): 135-141. doi: 10.1038/nsmb.1969.

Abstract

Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a β-sheet of the membrane-distal ectodomain of SLAM using the side of its β-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their β-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H–SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.

話の流れに注目してください。

＜最初の一文で背景＞

① Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor.

＜結果・結論＞

② Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM.

③ The MV-H head domain binds to a β-sheet of the membrane-distal ectodomain of SLAM using the side of its β-propeller fold.

④ This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their β-propeller.

↓

⑤ The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations.

⑥ Notably, the crystal structures obtained show two forms of the MV-H–SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.

特に、②の文からの流れに注目してください。

まず②の文を 『Here we present ~』 で始めて、「構造を明らかにした」というメインの結果が述べられています。③の文ではその構造の詳細を述べています。

特異的な構造であることを④の文で述べた後、その構造の応用性を⑤、⑥の文で述べています。